IBI3003 is a novel trispecific antibody targeting G protein-coupled receptor C5D (GPRC5D), B-cell maturation antigen (BCMA), and CD3... Patients with prior BCMA- and/or GPRC5D-targeted therapy were also eligible for enrollment.
the median time to peak expansion was day 15 (range 8–22); the median peak CAR transgene copy number was 112,981.7 copies/μg DNA; soluble BCMA (sBCMA) levels declined below the limit of detection in all 9 patients after infusion.